Jen-Yung Chen

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Receptive fields of sensory neurons in the brain are usually restricted to a portion of the entire stimulus domain. At all levels of the gustatory neuraxis, however, there are many cells that are broadly tuned, i.e., they respond well to each of the basic taste qualities (sweet, sour, salty, and bitter). Although it might seem that this broad tuning(More)
Spike timing-dependent plasticity (STDP) and other conventional Hebbian-type plasticity rules are prone to produce runaway dynamics of synaptic weights. Once potentiated, a synapse would have higher probability to lead to spikes and thus to be further potentiated, but once depressed, a synapse would tend to be further depressed. The runaway synaptic(More)
In the nucleus of the solitary tract (NTS), electrophysiological responses to taste stimuli representing four basic taste qualities (sweet, sour, salty, or bitter) can often be discriminated by spike count, although in units for which the number of spikes is variable across identical stimulus presentations, spike timing (i.e., temporal coding) can also(More)
The signature of slow-wave sleep in the electroencephalogram (EEG) is large-amplitude fluctuation of the field potential, which reflects synchronous alternation of activity and silence across cortical neurons. While initiation of the active cortical states during sleep slow oscillation has been intensively studied, the biological mechanisms which drive the(More)
Slow oscillation is the main brain rhythm observed during deep sleep in mammals. Although several studies have demonstrated its neocortical origin, the extent of the thalamic contribution is still a matter of discussion. Using electrophysiological recordings in vivo on cats and computational modeling, we found that the local thalamic inactivation or the(More)
Homosynaptic Hebbian-type plasticity provides a cellular mechanism of learning and refinement of connectivity during development in a variety of biological systems. In this review we argue that a complimentary form of plasticity-heterosynaptic plasticity-represents a necessary cellular component for homeostatic regulation of synaptic weights and neuronal(More)
Sensory neurons are generally tuned to a subset of stimulus qualities within their sensory domain and manifest this tuning by the relative size of their responses to stimuli of equal intensity. However, response size alone cannot unambiguously signal stimulus quality, since response size also depends on stimulus intensity. Thus a common problem faced by(More)
Honey bees have a rich repertoire of olfactory learning behaviors, and they therefore are an excellent model to study plasticity in olfactory circuits. Recent behavioral, physiological, and molecular evidence suggested that the antennal lobe, the first relay of the olfactory system in insects and analog to the olfactory bulb in vertebrates, is involved in(More)
The contribution of gustation to the perception of food requires an understanding of how neurons represent mixtures of taste qualities. In the periphery, separate groups of fibers, labeled by the stimulus that evokes the best (largest) response, appear to respond to each component of a mixture. In the brain, identification of analogous groups of neurons is(More)
In the brain, complex information interactions among neurons span several spatial and temporal scales, making it extremely difficult to identify the principles governing neural information processing. In this study, we used computational models to investigate the impact of dendritic morphology and synaptic topology on patterns of neuronal firing. We first(More)