Jen-Huang Huang

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Synthetic microvascular networks are essential to enable in vitro studies of cell biology, biophysics, hemodynamics, and drug discovery, as well as in applications involving tissue engineering and artificial vasculature. But current limitations make it challenging to construct networks incorporating a hierarchy of microchannel diameters that possess(More)
The ability to harness enzymatic activity as an etchant to precisely machine biodegradable substrates introduces new possibilities for microfabrication. This flow-based etching is straightforward to implement, enabling patterning of microchannels with topologies that incorporate variable depth along the cross-sectional dimension. Additionally, unlike(More)
We show how enzymatic activity can be harnessed as a tool to fashion complex nanoand micro-scale surface topographies on biodegradable substrates. Coordinated patterning and machining are accomplished by manipulating interactions between an enzyme, substrate, and protein inhibitor. In this way, we are able to construct nanochannels, microchannels containing(More)
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