Jen-Chun Kuan

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BACKGROUND Cohort studies evaluating increased serum uric acid (SUA) level as a chronic kidney disease (CKD) risk factor have yielded variable results. We aimed to assess the association between the pattern of longitudinal changes in SUA and incident CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)]. METHODS A population-based cohort(More)
1Division of Colorectal Surgery, Department of Surgery, and 7Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, No.325, Sec.2, Chenggong Rd., Neihu District, Taipei, Taiwan (Republic of China) 2Graduate Institute of Life Sciences, and 3School of Public Health, National Defense Medical Center, No.161 Sec. 6, Minquan(More)
BACKGROUND AND OBJECTIVES Cognitive impairment develops with pre-diabetes and dementia is a complication of diabetes. Natural products like turmeric and cinnamon may ameliorate the underlying pathogenesis. METHODS People ≥ 60 years (n=48) with newly-recognised untreated pre-diabetes were randomised to a double-blind metabolic study of placebo, turmeric (1(More)
The purpose of this study was to evaluate whether the apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio is a promising risk predictor of metabolic syndrome (MetS) and to determine the optimal cut-off value of this ratio in detecting subjects with MetS in a Chinese population. A prospective study was conducted using a representative sample of(More)
A new noninvasive screening tool for colorectal neoplasia detects epigenetic alterations exhibited by gastrointestinal tumor cells shed into stool. There is insufficient existing data to determine temporal associations between colorectal cancer (CRC) progression and aberrant DNA methylation. To evaluate the feasibility of using fecal DNA methylation status(More)
Aberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited. We examined DNA methylation in tumors and adjacent normal tissues from patients who underwent CRC surgical resection,(More)
Human bocaviruses (HBoVs) have been detected in human gastrointestinal infections worldwide. Although HBoV global prevalence and strains diversity have been reported, but epidemiological data from Taiwan is largely unavailable to date. A total of 110 fecal samples from stools of diarrheic children at a general hospital, Taiwan, obtained from August 2012 to(More)
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