Jen C. Dyer

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BACKGROUND Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactions between proteins and small-molecule chemical ligands. However, few CID systems are currently available. The properties of, and interactions(More)
Many laboratory strains of Escherichia coli are resistant to methotrexate (MTX), a folate analogue that binds dihydrofolate reductase (DHFR). Mutations that inactivate either tolC or acrA confer MTX sensitivity. Further, overexpression of a fusion protein with DHFR activity reverses this sensitivity by titrating out intracellular MTX. These results suggest(More)
Two activites causing nitrite disappearance are found in extracts of Neurospora; one, inducible by nitrate or nitrite and present only in nitrite-utilizing strains, catalyze the stoichiometric reduction of nitrite to ammonia; the other, present in all strains under all conditions, causes the disappearance of nitrite to something other than ammonia. The(More)
Partnership working is necessary to allow nations to harness the evolving opportunities presented by climate finance and to progress towards climate compatible development (CCD). However, the new multi-stakeholder partnerships being formed and the factors affecting their outcomes remain poorly understood. This paper aims to identify the characteristics of(More)
Farmers’ perceptions of how rainfall is changing is crucial in anticipating the effects of climate change, as only farmers who perceive a problem will adapt to it. However, even within the same location, people may perceive rainfall changes differently. Therefore, how can scientists, practitioners, and farmers ensure that they talk about the same rainfall(More)
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