Jenée Patane

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CONTEXT The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may affect weight loss. OBJECTIVE To determine the relationship between increasing doses of exogenous leptin administration and weight loss in both lean and obese adults. DESIGN A randomized, double-blind, placebo-controlled,(More)
Complement activation at the C3 convertase level has been associated with acute neuroinflammation and secondary brain injury after severe head trauma. The present study was designed to test the hypothesis that Cr2 -/- mice, which lack the receptors CR2/CD21 and CR1/CD35 for complement C3-derived activation fragments, are protected from adverse sequelae of(More)
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