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MicroRNAs (miRNAs) are small non-coding RNAs, which function as critical posttranscriptional regulators of gene expression by promoting mRNA degradation and translational inhibition. Placenta expresses many ubiquitous as well as specific miRNAs. These miRNAs regulate trophoblast cell differentiation, proliferation, apoptosis, invasion/migration, and(More)
The placenta is a transient organ that forms during pregnancy to support the growth and development of the fetus. During human placental development, trophoblast cells differentiate through two major pathways. In the villous pathway, cytotrophoblast cells fuse to form multinucleated syncytiotrophoblast. In the extravillous pathway, cytotrophoblast cells(More)
p27(Kip1), a cyclin-dependent kinase (CDK) inhibitor, is a multi-functional protein that regulates various cellular activities. Trophoblast proliferation, migration and invasion are some of the key processes of placental development. We have recently reported that Nodal, a member of the transforming growth factor-β (TGF-β) superfamily, inhibits human(More)
Platelet P-selectin plays important roles in inflammation and contributes to thrombosis and hemostasis. Although it has been reported that von Willebrand factor (VWF) affects P-selectin expression on endothelial cells, little information is available regarding regulation of platelet P-selectin expression. Here, we first observed that P-selectin expression(More)
Eight cases of carotid cavernous fistulas are reported. Electroencephalograms were done before, during and after operative attack und during digital carotid compression. Preoperative, there was a mild general slowing, ipsilaterally marked in the parieto-temporal region. During digital carotid compression slowing may be found on the opposite side because of(More)
In the period 1980-1993, in Belgrade, malignant tumors of the age group up to 24 years were 1.2% of the mortality structure of all cancers. The average standardized mortality rate (world standard population) of all cancers was 7.0 per 100,000 with a decreasing trend. In childhood and adolescence period, hematological malignancies (42.0%), brain tumors(More)