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  • Karin Kleigrewe, Jehad Almaliti, +9 authors William H. Gerwick
  • Biology, Medicine
  • Journal of natural products
  • 2015 (First Publication: 7 July 2015)
  • An innovative approach was developed for the discovery of new natural products by combining mass spectrometric metabolic profiling with genomic analysis and resulted in the discovery of theContinue Reading
  • Jehad Almaliti, Ayad A. Al-Hamashi, +5 authors L. M. Viranga Tillekeratne
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2016 (First Publication: 21 November 2016)
  • A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were synthesized. Replacing the thiazole-thiazolineContinue Reading
  • Paul D Boudreau, Bailey W. Miller, +7 authors William H. Gerwick
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2019 (First Publication: 20 September 2019)
  • Gallinamide A, originally isolated with modest antimalarial activity, was subsequently re-isolated and characterized as a potent, selective, and irreversible inhibitor of the human cysteine proteaseContinue Reading
  • Jehad Almaliti, Karla L. Malloy, Evgenia Glukhov, Carmenza Spadafora, Marcelino Gutiérrez, William H. Gerwick
  • Biology, Medicine
  • Journal of natural products
  • 2017 (First Publication: 23 May 2017)
  • A family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A-D (1-4), was isolated from a Papua New Guinean field collection of the cyanobacteriumContinue Reading
  • Jehad Almaliti, Shadia E. Nada, Bryaune Carter, Zahoor Ahmad Shah, L. M. Viranga Tillekeratne
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2013 (First Publication: 1 March 2013)
  • Stroke is a debilitating disease and the third leading cause of death in the USA, where over 2000 new stroke cases are diagnosed every day. Treatment options for stroke-related brain damage are veryContinue Reading