Jeffrey Zhang

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OBJECTIVE To evaluate efficacy and safety of ramelteon (MT1/MT2-receptor [corrected] agonist) in subjects with chronic primary insomnia. METHODS Randomized, multicenter, double-blind, placebo-controlled trial of nightly ramelteon treatment (8 mg or 16 mg) in adults (N=405) with primary chronic insomnia (DSM-IV-TR). Latency to persistent sleep (LPS), TST,(More)
OBJECTIVE To evaluate the long-term safety and subjective sleep effects of ramelteon in adults with chronic insomnia. METHOD Subjects with primary insomnia (DSM-IV-TR criteria) for >or= 3 months received ramelteon nightly for 1 year; a 3-day placebo run out followed. Subjects aged >or=65 years received open-label ramelteon 8 mg (N = 248); those aged 18 to(More)
Obtaining a digital model of a real-world 3D scene is a challenging task pursued by computer vision and computer graphics. Given an initial approximate 3D model, a popular refinement process is to perform a bundle adjustment of the estimated camera position, camera orientation, and scene points. Unfortunately, simultaneously solving for both camera position(More)
BACKGROUND Double-blind, randomized clinical trials are the preferred approach to demonstrating the effectiveness of one treatment against another. The comparison is, however, made on the average group effects. While patients and clinicians have always struggled to understand why patients respond differently to the same treatment, and while much hope has(More)
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