Jeffrey Weidner

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Four newborn calves from different herds were examined because of recumbency and inability to rise. Abnormal physical findings were confined to the nervous and/or musculoskeletal systems. Because of poor prognosis, all calves were euthanatized and necropsied. The histopathologic findings were multifocal lymphocytic myelitis, meningitis, and encephalitis(More)
The influences of facial airflow, exercise and wearing a facemask on gas exchange and upper airway (Pu), transpulmonary (PTP) and transdiaphragmatic (PTD) pressures were investigated in 6 horses performing an incremental exercise test on an inclined (10%) treadmill. The test consisted of a 2 min walk followed by two 2 min exercise bouts at intensities which(More)
On the basis of clinical and laboratory examinations, a ventricular septal defect or a variant of the tetralogy of Fallot was suspected in a 3-year-old filly with a history of poor growth rate and exercise intolerance. The filly was euthanatized and found to have a 3-chambered heart (cor triloculare biatriatum). The heart had 2 normally formed atria and a(More)
To develop novel treatments for type 2 diabetes and dyslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT). To this end compounds 1 and 2 were developed as potent SPT inhibitors in vitro. 1 and 2 reduce plasma ceramides in rodents, have a slight trend toward enhanced insulin sensitization in DIO mice, and reduce triglycerides and raise(More)
Interleukin-1 [3 (IL-l[3)-converting enzyme (ICE) is a novel cysteine protease that cleaves the 31-kD inactive cytoplasmic IL-113 precursor into active extracellular 17-kD IL-113. The ICE gene product is a 45-kD proenzyme that requires proteolytic processing to activate ICE. Active ICE is a heterodimer consisting of equal amounts of p20 and p l0 subunits.(More)
A 17-year-old Quarter Horse mare was examined nearly 3 years after excision and cryotherapy of a papillary mammary gland adenocarcinoma. The mare had been used for pleasure riding since surgery, but had recently developed progressive dyspnea. The mare had clinical evidence of pleural effusion, but died before further clinical examination and treatment were(More)
We have demonstrated spontaneous nitric oxide (NO) production by primary synovial cultures from rheumatoid (RA) and osteoarthritis patients. Increased NO production followed addition of staphylococcal enterotoxin B. Immunochemical double staining with specific anti-human inducible NO synthase (iNOS) and nonspecific esterase (NSE), or anti-CD68 (markers for(More)
CH50, C4, C2, and C3 levels were evaluated in 7 dogs affected with dermatomyositis and in 22 control dogs. Dogs with dermatomyositis did not have clinical evidence of active disease at the time of serum collection for complement assays. No absolute complement component deficiency was identified in dermatomyositis-affected dogs in this study; however, a(More)