Jeffrey V. Wells

Learn More
There have been reported cases of long-term symptomless human immunodeficiency virus type 1 (HIV-1) infection, but it is not clear whether the benign course of infection was due to host, viral, or other unknown factors. During follow-up of subjects with transfusion-acquired HIV-1 infection in New South Wales, Australia, we identified a group of 6 subjects(More)
An immunoassay was developed for the detection of sulfamethoxazole reactive IgE antibodies in the sera of patients who experienced life threatening anaphylactic reactions following the ingestion of co-trimoxazole (trimethoprim and sulfamethoxazole). Patients who had significant levels of sulfamethoxazole reactive IgE antibodies in their sera did not have(More)
Serum levels of complement components (C3 and C4) were measured serially in 173 initially normotensive pregnant women and the results compared with those obtained in 32 nonpregnant women of similar ages. There was significant elevation of serum levels of both C3 and C4 during gestation. Pregnancy-associated hypertension developed in the third trimester in(More)
Adverse reactions to human plasma proteins range from mild urticaria to fatal anaphylaxis and may occur with virtually any blood product. The most common clinical settings appear to be whole blood transfusion in subjects with no previous history of reactions, or the infusion of fresh frozen plasma or injection of human immune serum globulin (HISG) to(More)
Several antibodies have been reported in selective IgA deficiency and we have detected antibodies to human IgM and native human collagen in 35 and 34%, respectively, of 60 such subjects (compared to 1.6 and 2.0%, respectively, in normal controls). The anti-IgM isoantibodies are clearly distinguishable from antibodies to ruminant proteins and there was no(More)
IgA secretion and intracellular IgA synthesis by PWM-stimulated peripheral blood lymphocytes from normal and IgA deficient subjects were measured by radioimmunoassay. Cultured lymphocytes from eleven out of twelve IgA deficient subjects had impaired or undetectable IgA production. Measurement of intracellular IgA showed that the defect was more basic than(More)