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Dynamic images of natural objects exhibit significant correlations in k-space and time. Thus, it is feasible to acquire only a reduced amount of data and recover the missing portion afterwards. This leads to an improved temporal resolution, or an improved spatial resolution for a given amount of acquisition. Based on this approach, two methods were(More)
Mutual information (MI) is an increasingly popular match metric for multimodality image registration. However, its value is affected by interpolation, which may limit registration accuracy. The purpose of this study was to characterize the artifacts from eight interpolators and to investigate efficient strategies to overcome these artifacts. The(More)
Plant innate immunity is mediated by Resistance (R) proteins, which bear a striking resemblance to animal molecules of similar function. Tobacco N is a TIR-NB-LRR R gene that confers resistance to Tobacco mosaic virus, specifically the p50 helicase domain. An intriguing question is how plant R proteins recognize the presence of pathogen-derived Avirulence(More)
The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism of the Smoothened receptor (Smo). Structure-activity relationship studies led to the discovery of a(More)
By exploiting spatiotemporal correlations in cardiac acquisitions using k-t BLAST, gated cine 3D acquisitions of the heart were accelerated by a net factor of 4.3, making single breathhold acquisitions possible. Sparse sampling of k-t space along a sheared grid pattern was implemented into a cine 3D SSFP sequence. The acquisition of low-resolution training(More)
In recent years, there has been an explosive growth of magnetic resonance imaging (MRI) techniques that allow faster scan speed by exploiting temporal or spatiotemporal redundancy of the images. These techniques improve the performance of dynamic imaging significantly across multiple clinical applications, including cardiac functional examinations,(More)
Conventional phase-contrast velocity mapping in the ascending aorta was combined with k-t BLAST and k-t SENSE. Up to 5.3-fold net acceleration was achieved, enabling single breath-hold acquisitions. A standard phase-contrast (PC) sequence with interleaved acquisition of the velocity-encoded segments was modified to collect data in 2 stages, a(More)
PURPOSE To substantially improve spatial localization in magnetic resonance spectroscopic imaging (MRSI) accelerated by parallel imaging. This is important in order to make MRSI more reliable as a tool for clinical applications. METHODS The sensitivity encoding acceleration technique with spatial overdiscretization is applied for the reconstruction of(More)
In k-t BLAST and k-t SENSE, data acquisition is accelerated by sparsely sampling k-space over time. This undersampling in k-t space causes the object signals to be convolved with a point spread function in x-f space (x = spatial position, f = temporal frequency). The resulting aliasing is resolved by exploiting spatiotemporal correlations within the data.(More)