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  • Daniel J. Rader, Eric T. Alexander, Ginny L Weibel, Jeffrey T. Billheimer, George H. Rothblat
  • Medicine, Biology
  • Journal of lipid research
  • 2009 (First Publication: 1 April 2009)
  • Reverse cholesterol transport (RCT) is a term used to describe the efflux of excess cellular cholesterol from peripheral tissues and its return to the liver for excretion in the bile and ultimatelyContinue Reading
  • Peter Oelkers, Debra A Cromley, Mahajabeen Padamsee, Jeffrey T. Billheimer, Stephen L. Sturley
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2002 (First Publication: 15 March 2002)
  • Diacylglycerol esterification provides an excellent target for the pharmacological reduction of triglyceride accumulation in several human disease states. We have used Saccharomyces cerevisiae as aContinue Reading
  • Peter Oelkers, Amit Awath Behari, Debra A Cromley, Jeffrey T. Billheimer, Stephen L. Sturley
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1998 (First Publication: 9 October 1998)
  • The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol esterification, a crucial component of intracellular lipid homeostasis. Two enzymes catalyze this activity inContinue Reading
  • Yuzhen Zhang, J R da Silva, Muredach P. Reilly, Jeffrey T. Billheimer, George H. Rothblat, Daniel J. Rader
  • Medicine
  • The Journal of clinical investigation
  • 2005 (First Publication: 1 October 2005)
  • Hepatic expression of the scavenger receptor class B type I (SR-BI) promotes selective uptake of HDL cholesterol by the liver and is believed to play a role in the process of reverse cholesterolContinue Reading
  • Peter Oelkers, Arthur H. Tinkelenberg, Naz Erdeniz, Debra A Cromley, Jeffrey T. Billheimer, Stephen L. Sturley
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2000 (First Publication: 26 May 2000)
  • The terminal step in triglyceride biosynthesis is the esterification of diacylglycerol. To study this reaction in the model eukaryote, Saccharomyces cerevisiae, we investigated five candidate genesContinue Reading
  • John S Millar, Debra A Cromley, Mary G. McCoy, Daniel J. Rader, Jeffrey T. Billheimer
  • Chemistry, Medicine
  • Journal of lipid research
  • 2005 (First Publication: 1 September 2005)
  • Triglyceride (TG), a water-insoluble energy-rich lipid, is secreted by the liver as part of very low density lipoproteins (VLDLs) to supply energy to extrahepatic tissues. Overproduction of VLDL isContinue Reading
  • Dong Ping Cheng, Thomas C. Nelson, +7 authors John N. Feder
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2003 (First Publication: 18 April 2003)
  • Acyl coenzyme A:monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerol using 2-monoacylglycerol and fatty acyl coenzyme A. This enzymatic reaction is believed to be anContinue Reading
  • Hiroyuki Tanigawa, Jeffrey T. Billheimer, Jun-ichiro Tohyama, Yuzhen Zhang, George H. Rothblat, Daniel J. Rader
  • Biology, Medicine
  • Circulation
  • 2007 (First Publication: 11 September 2007)
  • BACKGROUND Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from high-density lipoproteins to apolipoprotein (apo) B-containing lipoproteins and in humans plays an importantContinue Reading