Jeffrey T Patrick

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Glycine, GABA, aspartate and glutamate are putative neurotransmitters in the mammalian spinal cord. The distribution of these amino acids was determined in the rat spinal cord. Transversely, the highest levels of glycine, aspartate and glutamate were in the intermediate and ventral gray; whereas, the highest levels of GABA were in the dorsal gray.(More)
Acetaminophen (paracetamol) is a widely used nonopioid, non-NSAID analgesic that is effective against a variety of pain types, but the consequences of overdose can be severe. Because acetaminophen is so widely available as a single agent and is increasingly being formulated in fixed-ratio combination analgesic products for the potential additive or(More)
The high-affinity uptake of [3H]serotonin, [3H]glutamate, and [3H]gamma-aminobutyric acid [( 3H]GABA) and the Na+-independent binding of [3H]glutamate and [3H]GABA were studied using spinal cord preparations obtained from normal mongrel dogs and from dogs made paraplegic by midthoracic spinal cord crush. Lumbosacral regions of the spinal cord were removed(More)
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