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PROBLEM T-helper 2 (TH2)-type cytokines [i.e., interleukin (IL)-6, IL-10, and IL-13] and transforming growth factor (TGF)-beta are expressed by the murine decidua and/or placenta and are likely to suppress inflammatory cytokine [i.e., IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-1 alpha, and IL-1 beta] production at the maternal-fetal… (More)
PROBLEM Communication at the human maternal-fetal interface occurs by an intricate cytokine network. This study examines cytokine expression by normal first-trimester human chorionic villi. METHOD OF STUDY Tissues were obtained at elective pregnancy terminations (7-9 weeks). Total RNA was isolated from chorionic villi by guanidinium isothiocynate-acid… (More)
The uterus contains all the components of a tertiary lymphoid compartment. We hypothesize that specific leukocyte recruitment to the endometrium during the secretory phase of the menstrual cycle and early pregnancy limits the type of immunocyte that gains access. The present study utilized flow cytometry to define and quantify adhesion molecules possibly… (More)
A fast new algorithm is used compute the zeros of 10 6 quadratic character L-functions for negative fundamental discrim-inants with absolute value d > 10 12. These are compared to the 1-level density, including various lower order terms. These terms come from, on the one hand the Explicit Formula, and on the other the L-functions Ratios Conjecture. The… (More)
An algorithm is given to efficiently compute L-functions with large conductor in a restricted range of the critical strip. Examples are included for about 24000 dihedral Galois representations with conductor near 10 7. The data shows good agreement with a symplectic random matrix model.
We apply Tatuzawa's version of Siegel's theorem to derive two lower bounds on the size of the principal genus of positive definite binary quadratic forms.
An algorithm is given to efficiently compute, for large discriminant, L-functions of characters on the class group of a complex quadratic field. This is an analog in conductor aspect of the Odlyzko-Schönhage algorithm to compute the Riemann zeta function. Examples are included for about 21000 L-functions with conductor near 10 7. The data shows good… (More)