Jeffrey Springer

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We used a decadal data set, with weekly to biweekly sampling in April–October and monthly sampling in November– March, to characterize climatic (hurricane-level storms, a sustained 3-yr drought) and anthropogenic influences on N and P concentrations and loadings to a large eutrophic, poorly flushed estuary, the Neuse Estuary of the Albemarle–Pamlico(More)
BACKGROUND Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea-pigs large-diameter, neurofilament-positive airway neurons. OBJECTIVE In the present study, the effect of NGF on tyrosine kinase receptor trkA and the capsaicin receptor TRPV1(More)
The potent vasodilatory peptide, calcitonin gene-related peptide (CGRP) is present in the innervation of vascular tissue. The actions of CGRP occur via a receptor, CGRP receptor(R)-1, which is also a target for the cardioprotective peptide adrenomedullin. The human version of the pharmacologically-defined CGRPR-1 has been cloned but its distribution and(More)
C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative(More)
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