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Regulatory T cells (T(REGs)) control the key aspects of tolerance and play a role in the lack of antitumor immune responses. Cyclophosphamide (CY) is a chemotherapeutic agent with a dose-dependent,Expand
  • Philip W. Kantoff, Thomas Joseph Schuetz, +11 authors Wayne R. Godfrey
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2010 (First Publication: 1 March 2010)
  • PURPOSE Therapeutic prostate-specific antigen (PSA) -targeted poxviral vaccines for prostate cancer have been well tolerated. PROSTVAC-VF treatment was evaluated for safety and for prolongation ofExpand
  • Romaine Ingrid Fernando, Mary T. Litzinger, Paola Trono, Duane H. Hamilton, Jeffrey Schlom, Claudia Palena
  • Medicine, Biology
  • The Journal of clinical investigation
  • 2010 (First Publication: 1 February 2010)
  • Metastatic disease is responsible for the majority of human cancer deaths. Understanding the molecular mechanisms of metastasis is a major step in designing effective cancer therapeutics. Here weExpand
  • Eric A. J. Reits, James W Hodge, +14 authors Jacques Neefjes
  • Biology, Medicine
  • The Journal of experimental medicine
  • 2006 (First Publication: 15 May 2006)
  • Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on antigen presentation by MHC class I molecules was studied. Cell surface expression of MHC class IExpand
  • Kwong Yok Tsang, Stanisław Zaremba, Carol Nieroda, Ming Zhu Zhu, Jeffrey Hamilton, Jeffrey Schlom
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 1995 (First Publication: 5 July 1995)
  • BACKGROUND The human carcinoembryonic antigen (CEA), which is expressed in several cancer types, is a potential target for specific immunotherapy using recombinant vaccines. Previous studies haveExpand
  • Stanisław Zaremba, Elena Barzaga, Ming Zhu Zhu, Nunes Soares, Kwong Yok Tsang, Jeffrey Schlom
  • Biology, Medicine
  • Cancer research
  • 1997 (First Publication: 15 October 1997)
  • A vaccination strategy designed to enhance the immunogenicity of self-antigens that are overexpressed in tumor cells is to identify and slightly modify immunodominant epitopes that elicit T-cellExpand
  • Charlie T. Garnett, Claudia Palena, Mala Chakarborty, Kwong-Yok Tsang, Jeffrey Schlom, James W Hodge
  • Medicine, Biology
  • Cancer Research
  • 2004 (First Publication: 1 November 2004)
  • Local radiation of tumor masses is an established modality for the therapy of a range of human tumors. It has recently been recognized that doses of radiation, lower than or equal to those that causeExpand