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Two cases of yeast infection of prosthetic joints, caused by Torulopsis glabrata and Candida albicans are described. One case occurred 27 months after joint insertion. Neither patient had an underlying illness predisposing them to infection. Removal of the prosthetic device appears necessary for cure of such infection.
An adjuvant role for certain short bacterial immunostimulatory DNA sequences (ISSs) has recently been proposed on the basis of their ability to stimulate T helper-1 (Th1) responses in gene-vaccinated animals. We report here that noncoding, ISS-enriched plasmid DNAs or ISS oligonucleotides (ISS-ODNs) potently stimulate immune responses to coadministered… (More)
BACKGROUND In animal models, expression of nerve growth factor (NGF) is increased after necrotic myocardial injury. Whether radiofrequency (RF) catheter ablation increases NGF expression in humans is unclear. OBJECTIVES The purpose of this study was to determine NGF concentrations in the aorta, coronary sinus, and peripheral veins before and after RF… (More)
This paper examines whether an older patient's concerns about surgical treatment of breast cancer--such as fear of dying or about losing a breast--affect the treatment recommendations by their surgeons. A sample of 137 older women diagnosed with early stage breast cancer between 1994 and 1996 were interviewed within 2 months of diagnosis to determine… (More)
Genetic immunization is a relatively new approach to vaccination, one that has generated considerable interest for its potential to prevent or treat a number of types of disease processes. Although initial work focused on potential applications in infectious disease, it was soon recognized that the antigen-specific Th1 response typically generated by… (More)