Jeffrey S. Buzas

Learn More
—We propose NM landscapes as a new class of tunably rugged benchmark problems. NM landscapes are well-defined on alphabets of any arity, including both discrete and real-valued alphabets, include epistasis in a natural and transparent manner, are proven to have known value and location of the global maximum and, with some additional constraints, are proven(More)
Widespread unexplained variations in clinical practices and patient outcomes suggest major opportunities for improving the quality and safety of medical care. However, there is little consensus regarding how to best identify and disseminate healthcare improvements and a dearth of theory to guide the debate. Many consider multicenter randomized controlled(More)
BACKGROUND Fractionated electrograms are used by some as targets for ablation in atrial and ventricular arrhythmias. Fractionation has been demonstrated to result when there is repetitive or asynchronous activation of separate groups of cells within the recording region of a mapping electrode(s). METHODS AND RESULTS Using a computer model, we generated(More)
and major morbidities among survivors declined. WHAT THIS STUDY ADDS: Obstetrical and neonatal care practices for infants 501 to 1500 g changed significantly from 2000 and 2009, particularly decreased conventional ventilation and use of steroids for chronic lung disease and increased nasal continuous positive airway pressure and surfactant treatment after(More)
—Simulated landscapes have been used for decades to evaluate search strategies whose goal is to find the landscape location with maximum fitness. Understanding properties of landscapes is important for understanding search difficulty. This paper presents a novel and transparent characterization of NK landscapes and derives an analytic expression(More)
We develop an algorithm to evolve sets of probabilistically significant multivariate feature interactions, with co-evolved feature ranges, for classification in large, complex datasets. The datasets may include nominal, ordinal, and/or continuous features, missing data, imbalanced classes, and other complexities. Our age-layered evolutionary algorithm(More)
Simulated landscapes have been used for several decades to evaluate search strategies whose goal is to find the landscape location with maximum fitness. Applications of simulated landscapes include modeling the capacity of enzymes to catalyze reactions or ligands to bind to proteins, and the clinical effectiveness of medical treatments. Understanding(More)
  • 1