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Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder
A model is presented which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity is suggested.
Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder.
Right orbital cortex/hem was significantly correlated with ipsilateral Cd/hem and thalamus/hem before treatment but not after, and the differences before and after treatment were significant, suggesting a brain circuit involving these brain regions may mediate obsessive-compulsive disorder symptoms.
Reduction of prefrontal cortex glucose metabolism common to three types of depression.
Using positron emission tomography, we studied cerebral glucose metabolism in drug-free, age- and sex-matched, right-handed patients with unipolar depression (n = 10), bipolar depression (n = 10),
Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder.
Findings in this study replicate and extend previous findings of changes in caudate nucleus function with behavior therapy for obsessive-compulsive disorder.
The Mind and the Brain: Neuroplasticity and the Power of Mental Force
The greatest scientific advances are never the result of strict adherence to convention. Often it takes an innovative maverick, someone willing to see things differently while possessing the
Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls.
In OCD, metabolic rates were significantly increased in the left orbital gyrus and bilaterally in the caudate nuclei, and cerebral glucose metabolic patterns that differed from controls in both the symptomatic and recovered states.
Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder
Compared to controls, OCD patients showed significant bilateral decreases in normalized thalamic metabolism with intensive CBT but had a significant increase in right dorsal anterior cingulate cortex activity that correlated strongly with the degree of improvement in OCD symptoms, which improved robustly with treatment.
Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.
The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state, and patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole.
Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder.
The authors compared 10 nondepressed patients with obsessive-compulsive disorder with 10 normal control subjects of the same sex and similar age for cerebral glucose metabolic rates obtained using
Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers.
A metabolic mechanism for the atherogenic effects of CS on serum lipids (increased hepatic reesterification of FFA) has been documented, and increased entry of F FA accounts for CS-induced increases in serum FFA concentrations.