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in vitro and in vivo association assays. The GST–cytoplasmic region of EGFR fusion proteins (amino acids 930–1,220, which do not include Lys 721, a key residue in the ATP-binding site) were generated as described 28. The in vitro Jak2 assay was done as before 2 , with minimal modification. Proteins immobilized on anti-Jak2 antibody were mixed with 95 ␮l of(More)
Previous exploration of oncology study design efficiency has focused on Markov processes alone (probability-based events) without consideration for time dependencies. Barriers to study completion include time delays associated with patient accrual, inevaluability (IE), time to dose limiting toxicities (DLT) and administrative and review time. Discrete event(More)
This investigation evaluated the impact of potential drug interactions on the incidence of reported toxicities seen with common dosing patterns in children with cancer, with the intent of being able to screen and reduce the incidence of adverse drug reactions (ADRs) in the future. Toxicity reported in pediatric cancer patients treated at the Children’s(More)
This systematic literature review describes adverse events (AEs) among patients with soft tissue sarcoma (STS) who received second-line or later anticancer therapies. Searches were conducted in PubMed, EMBASE, and Cochrane Central Register of Controlled Trials for studies of adults with advanced or metastatic STS who received systemic anticancer therapy(More)
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