Jeffrey L . Martini

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Intraprotein energy transfer to terbium ions is widely used for probing distances of calcium sites in proteins. In this work we have performed a time-resolved study of the sensitized luminescence in elastase using a pulsed laser excitation at 265 nm. Terbium-sensitized luminescence was found to build-up within about 150 microseconds, which indicates that(More)
The inhibition rates and spectral characteristics of 2 probes specific for the active-site serine residue of proteases were examined for evidence of conformational change of the proteases upon their binding to alpha 2-macroglobulin (alpha 2M). Elastase, chymotrypsin, trypsin, and plasmin were reacted with (7-nitrobenz-2-oxa-1,3-diazole) aminoethyl- and(More)
The values of clients, alcoholics and nonalcoholics (N = 118), were compared to the values of therapists (N = 45). Value comparisons were also made between alcoholics and nonalcoholics as well as between these subgroups and therapists. Distinctive value patterns emerged which were peculiar to therapists and to clients and differentiated them from each(More)