Jeffrey L. Duerk

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Magnetic resonance is an exceptionally powerful and versatile measurement technique. The basic structure of a magnetic resonance experiment has remained largely unchanged for almost 50 years, being mainly restricted to the qualitative probing of only a limited set of the properties that can in principle be accessed by this technique. Here we introduce an(More)
We evaluated semiautomatic, voxel-based registration methods for a new application, the assessment and optimization of interventional magnetic resonance imaging (I-MRI) guided thermal ablation of liver cancer. The abdominal images acquired on a low-field-strength, open I-MRI system contain noise, motion artifacts, and tissue deformation. Dissimilar images(More)
PURPOSE To perform a phase II clinical trial to evaluate efficacy and safety of interactive magnetic resonance (MR) imaging-guided radiofrequency (RF) interstitial thermal ablation (ITA) of primary renal tumors. MATERIALS AND METHODS Ten male patients (age range, 25-83 years) with peripheral renal cell carcinoma and contraindications to surgery were(More)
In this study, we registered live-time interventional magnetic resonance imaging (iMRI) slices with a previously obtained high-resolution MRI volume that in turn can be registered with a variety of functional images, e.g., PET, SPECT, for tumor targeting. We created and evaluated a slice-to-volume (SV) registration algorithm with special features for its(More)
OBJECTIVE This investigation was performed to test the hypotheses that interactive guidance of MR image acquisition during needle-directed procedures using a clinical 0.2-T C-arm open MR imaging system integrated with a frameless optically linked stereotaxy system is feasible, and that procedure times can be sufficiently short to be well tolerated by the(More)
OBJECTIVE The purpose of this investigation was to evaluate the accuracy of MR Imaging for needle depiction at 0.2 and 1.5 T with multiple pulse sequences and needle orientations. The goal was to provide a framework for biopsy approach and imaging technique parameter selection that will ensure the safety and accuracy of MR-guided procedures. MATERIALS AND(More)
PURPOSE To test the hypotheses that (a) magnetic resonance (MR) imaging-guided radio-frequency (RF) thermal ablation of the vertebrae is feasible in porcine models, (b) procedure safety depends on the location of ablation within the vertebra, and (c) MR imaging allows accurate monitoring of induced thermal lesion size and shape. MATERIALS AND METHODS Ten(More)
Fourteen percutaneous sclerotherapy procedures with magnetic resonance (MR) imaging guidance were performed in three patients with low-flow vascular malformations. All targeted vascular malformation compartments were filled with sclerosing agent without complications in a mean procedural time of 29 minutes. Follow-up imaging demonstrated reduction in size(More)
PURPOSE To determine whether consistent regions of activity could be observed in the lumbar spinal cord of single subjects with spin-echo functional MRI (fMRI) if several repeated experiments were performed within a single imaging session. MATERIALS AND METHODS Repeated fMRI experiments of the human lumbar spinal cord were performed at 1.5 T with a(More)
Echo shifted (ES) gradient-recalled echo sequences (whose TE > TR) have found important applications in fMRI and MR thermometry since their introduction. The technique increases T *(2) weighting in BOLD imaging and temperature change sensitivity in phase-based temperature imaging compared to FLASH sequences. Yet, inconsistent observations have previously(More)