• Publications
  • Influence
Antioxidants, redox signaling, and pathophysiology in schizophrenia: an integrative view.
TLDR
The body of evidence reviewed herein provides a theoretical rationale for the development of novel treatment approaches and burgeoning evidence indicating a link among oxidative stress, membrane defects, immune dysfunction, and multineurotransmitter pathologies in SZ. Expand
Altered Glutathione Redox State in Schizophrenia
TLDR
Levels of GSH, GSSG, GPx, GSH and GR were assessed in the caudate region of postmortem brains from schizophrenic patients and control subjects and positive correlations suggest a dynamic state is kept in check during the redox coupling under normal conditions. Expand
Reduced status of plasma total antioxidant capacity in schizophrenia
TLDR
Findings are indicative of an impaired antioxidant defense system, not attributable to neuroleptic treatment, and lend further support to the notion that oxidative stress may have a pathophysiological role in schizophrenia. Expand
Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients
TLDR
The present findings suggest that deficits identified in peripheral membranes may also be present in the brain from schizophrenic patients, and such a deficit in membrane AA may contribute to the many biological, physiological, and clinical phenomena observed in schizophrenia. Expand
Reduced plasma antioxidants in first-episode patients with schizophrenia
TLDR
The present data suggest that a defect in the antioxidant defense system (AODS), which may lead to oxidative damage, occurs early in the course of illness and is independent of treatment effects. Expand
Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults
TLDR
Higher reported consumption of the long-chain omega-3 fatty acids is associated with greater gray matter volume in nodes of a corticolimbic circuitry supporting emotional arousal and regulation, which may mediate previously observed effects of omega-2 fatty acids on memory, mood and affect regulation. Expand
Salivary cortisol responses in prepubertal boys: the effects of parental substance abuse and association with drug use behavior during adolescence
TLDR
Lower preadolescent anticipatory cortisol responses were associated with regular monthly cigarette smoking and regular monthly marijuana use during adolescence and Hyporeactivity as an adaptation to chronic stress may be salient to the intergenerational transmission of substance abuse liability. Expand
Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood.
TLDR
It is suggested that DHA is related to brain health throughout the lifespan and may have implications for clinical trials of neuropsychiatric disorders. Expand
Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse
TLDR
It is suggested that altered serotonergic function is associated with assaultiveness and dysphoria but not impulsivity in individuals with ASP, and the prolactin responses showed a significant inverse correlation with measures of assaultive aggression and hypophoria. Expand
...
1
2
3
4
5
...