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Antioxidants, redox signaling, and pathophysiology in schizophrenia: an integrative view.
TLDR
The body of evidence reviewed herein provides a theoretical rationale for the development of novel treatment approaches and burgeoning evidence indicating a link among oxidative stress, membrane defects, immune dysfunction, and multineurotransmitter pathologies in SZ.
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Altered Glutathione Redox State in Schizophrenia
TLDR
Levels of GSH, GSSG, GPx, GSH and GR were assessed in the caudate region of postmortem brains from schizophrenic patients and control subjects and positive correlations suggest a dynamic state is kept in check during the redox coupling under normal conditions.
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Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients
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Reduced status of plasma total antioxidant capacity in schizophrenia
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An Overview of the Evidence and Its Therapeutic Implications
Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline.
TLDR
It is shown that significant PUFA reductions occur early in the illness, prior to initiation of treatment, raising the possibility that these deficits are trait related and suggest that membrane fatty acid losses are quite specific to the highly unsaturated fatty acids.
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Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood.
TLDR
It is suggested that DHA is related to brain health throughout the lifespan and may have implications for clinical trials of neuropsychiatric disorders.
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Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults
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Reduced plasma antioxidants in first-episode patients with schizophrenia
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Salivary cortisol responses in prepubertal boys: the effects of parental substance abuse and association with drug use behavior during adolescence
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