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OBJECTIVE This study was undertaken to compare the rates of uterine rupture during induced trials of labor after previous cesarean delivery with the rates during a spontaneous trial of labor. STUDY DESIGN All deliveries between 1992 and 1998 among women with previous cesarean delivery were evaluated. Rates of uterine rupture were determined for(More)
OBJECTIVE The purpose of this study was to evaluate the incidence of peripartum myocardial ischemia in Canada. STUDY DESIGN We identified the cohort of women who were admitted to Canadian hospitals for delivery between 1970 and 1998 to calculate the incidence rate and to evaluate potential risk factors. RESULTS One hundred fourteen of 10,032,375 women(More)
OBJECTIVE Our purpose was to evaluate the effects of known stimulants of prostaglandin production on cultured myometrial cells from women in labor with and without intrauterine infection. STUDY DESIGN Myometrial segments were obtained from 16 patients between 33 and 40 weeks' gestation who had been in labor for > or = 8 hours at cesarean delivery; 8(More)
OBJECTIVE The purpose of this study was to determine and compare the incidences of uterine rupture among women with and without müllerian duct anomalies who were attempting vaginal birth after cesarean delivery. STUDY DESIGN There were 1813 attempts at vaginal birth after cesarean delivery between 1992 and 1997 at the Foothills Hospital in Calgary,(More)
PROBLEM Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. METHODS IL-1 beta, TNF alpha, and EGF induced a concentration-related(More)
OBJECTIVE To determine the rate of neonatal and childhood medical complications in the offspring of women with the antiphospholipid syndrome who are treated during pregnancy. METHODS We compared 29 infants born to 23 mothers with antiphospholipid syndrome with a group of control children matched for year and gestational age at birth and route of delivery.(More)
The objective of this study was to evaluate the effects of known stimulants of prostaglandin production on cultured myometrial cells from women who are at various gestational ages. To evaluate this, myometrial segments were obtained from 12 patients at 27-40 weeks gestation at cesarean delivery. Myometrial cells were then isolated and grown to confluence in(More)
The purpose of this study was to determine how tumor necrosis factor alpha (TNF alpha) stimulates prostaglandin E2 production in human amnion. Amnion cells were isolated from term placentae and grown to confluence in culture. Incubations were conducted in quadruplicate wells for 16 hours with TNF alpha and protein synthesis inhibitors cycloheximide and(More)
OBJECTIVE To evaluate the predictability of eclampsia and explore the role for seizure prophylaxis in a population with a low frequency of seizure prophylaxis. METHODS A retrospective review was conducted of all women with eclampsia registered at the Foothills Hospital in Calgary, Alberta, between 1991 and 2000. The data collected included timing of(More)
OBJECTIVE The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua. METHODS Decidual cells from term placentas were grown in culture until confluent. Incubations were performed with TNF(More)