Jeffrey J. Fredberg

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Scaling the microrheology of living cells.

Ben Fabry, Geoffrey N. Maksym, James P. Butler, Michael Glogauer, Daniel Navajas, Jeffrey J. Fredberg
Physical review letters
2001

We report a scaling law that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological… (More)

Traction fields, moments, and strain energy that cells exert on their surroundings.

James P. Butler, Iva Marija Tolic-Nørrelykke, Ben Fabry, Jeffrey J. Fredberg
American journal of physiology. Cell physiology
2002

Adherent cells exert tractions on their surroundings. These tractions can be measured by observing the displacements of beads embedded on a flexible gel substrate on which the cells are cultured.… (More)

Input impedance and peripheral inhomogeneity of dog lungs.

Zoltán Hantos, B. Daróczy, Béla Suki, Sandor Nagy, Jeffrey J. Fredberg
Journal of applied physiology
1992

Tracheal pressure, central airflow, and alveolar capsule pressures in cardiac lobes were measured in open-chest dogs during 0.1- to 20-Hz pseudorandom forced oscillations applied at the airway… (More)

Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells.

Ning Wang, Iva Marija Tolic-Nørrelykke, +4 authors Dimitrije Stamenović
American journal of physiology. Cell physiology
2002

The tensegrity hypothesis holds that the cytoskeleton is a structure whose shape is stabilized predominantly by the tensile stresses borne by filamentous structures. Accordingly, cell stiffness must… (More)

On the imperfect elasticity of lung tissue.

Jeffrey J. Fredberg, Dimitrije Stamenović
Journal of applied physiology
1989

This paper deals with a unifying hypothesis addressed at lung tissue resistance and its responses to neurohumoral and biophysical stimuli. The hypothesis holds that dissipative and elastic processes… (More)

Universal physical responses to stretch in the living cell

Xavier Trepat, Linhong Deng, +5 authors Jeffrey J. Fredberg
Nature
2007

With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse function are subjected to substantial stretch. Stretch is a potent stimulus for growth,… (More)

Physical forces during collective cell migration

Xavier Trepat, Michael Wasserman, +4 authors Jeffrey J. Fredberg
2009

Fundamental biological processes including morphogenesis, tissue repair and tumour metastasis require collective cell motions1–3, and to drive these motions cells exert traction forces on their… (More)

Mechanical behavior in living cells consistent with the tensegrity model.

Ning Wang, Kiyoshi Naruse, +6 authors Donald E. Ingber
Proceedings of the National Academy of Sciences…
2001

Alternative models of cell mechanics depict the living cell as a simple mechanical continuum, porous filament gel, tensed cortical membrane, or tensegrity network that maintains a stabilizing… (More)

Airway smooth muscle, tidal stretches, and dynamically determined contractile states.

Jeffrey J. Fredberg, Daniel K. Inouye, +5 authors Stephanie A. Shore
American journal of respiratory and critical care…
1997

In the classic theory of airway lumen narrowing in asthma, active force in airway smooth muscle is presumed to be in static mechanical equilibrium with the external load against which the muscle has… (More)

Collective cell guidance by cooperative intercellular forces

Dhananjay T Tambe, C. Corey Hardin, +9 authors Xavier Trepat
Nature materials
2011

Cells comprising a tissue migrate as part of a collective. How collective processes are coordinated over large multi-cellular assemblies has remained unclear, however, because mechanical stresses… (More)

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