Jeffrey J Stewart

Learn More
This paper provides an overview of the one-stage R&D portfolio optimization problem. It provides a novel problem model that can be solved with stochastic combinatorial optimization methods. Current solution methods are reviewed and a new method that scales to large problems, Stochastic Gradient Portfolio Optimization (SGPO), is proposed. Although SGPO is a(More)
BACKGROUND Many RNA viruses do not have a single, representative genome but instead form a set of related variants that has been called a quasispecies. The sequence variability of such viruses presents a significant bioinformatics challenge. In order for the sequence information to be understood, the complete mutational spectrum needs to be distilled to a(More)
  • 1