Jeffrey J. Ellison

Learn More
A. Water Exchange 2326 B. Proton Exchange 2327 C. Electronic Relaxation 2327 D. Relaxivity 2331 E. Outerand Second-Sphere Relaxivity 2334 F. Methods of Improving Relaxivity 2336 V. Macromolecular Conjugates 2336 A. Introduction 2336 B. General Conjugation Methods 2336 C. Synthetic Linear Polymers 2336 D. Synthetic Dendrimer-Based Agents 2338 E. Naturally(More)
Analysis of the iron K-edge X-ray absorption spectrum (XAS) of the “dark”, inactive form of nitrile hydratase (NHdk) from Rhodococcus sp. R312 confirms a 1:1 stoichiometry of nitric oxide bound to low-spin iron(III). We also report XAS analyses of four iron complexes of the pentadentate ligands(More)
The amphiphilic gadolinium complex MS-325 ((trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl) phosphonooxymethyl] diethylenetriaminepentaacetato) (aquo)gadolinium(III)}) is a contrast agent for magnetic resonance angiography (MRA). MS-325 consists of two slowly interconverting diastereoisomers, A and B (65:35 ratio), which can be isolated at pH > 8.5 (TyeklAr,(More)
To examine inhibitor binding to an iron site resembling that of the metalloenzyme nitrile hydratase (NHase), a coordinatively unsaturated, five-coordinate FeIII thiolate complex was synthesized, and its reactivity examined. Ferricinium hexafluorophosphate induced oxidation of gem-dimethyl-protected [FeS2N3(Pr,Pr)] affords the chiral, five-coordinate complex(More)
To examine how small structural changes influence the reactivity and magnetic properties of biologically relevant metal complexes, the reactivity and magnetic properties of two structurally related five-coordinate Fe(III) thiolate compounds are compared. (Et,Pr)-ligated [Fe(III)(S(2)(Me2)N(3)(Et,Pr))]PF(6) (3) is synthesized via the abstraction of a sulfur(More)
(Bottom) Structure of AngioMARKsa prototypic targeted contrast agent for magnetic resonance imaging (MRI) currently undergoing clinical trials. The hydrophobic bicyclohexyl moiety targets the plasma protein serum albumin, the octadentate moiety sequesters the toxic metal ion, and the paramagnetic gadolinium(III) ion and exchangeable water molecule provide(More)
The syntheses and structures of two analogous five-coordinate mixed nitrogen/thiolate-ligated Co2+ and Fe2+ complexes are described and compared to their previously reported Zn2+ and Ni2+ analogues. The linear, singlechain [S2N3(Pr,Pr)] (R ) H, Me) ligands examined in this study wrap themselves around metal ions in both a clockwise and counterclockwise(More)
  • 1