Jeffrey H Samet

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BACKGROUND Alcohol abuse has been associated with poor adherence to highly active antiretroviral therapy (HAART). We examined the relative importance of varying levels of alcohol consumption on adherence in HIV-infected patients with a history of alcohol problems. METHODS We surveyed 349 HIV-infected persons with a history of alcohol problems at 6-month(More)
OBJECTIVE To assess the relation between alcohol consumption and laboratory markers of HIV disease progression. METHODS We prospectively assessed CD4 cell counts, HIV RNA levels, and alcohol consumption for up to 7 years in 595 HIV-infected persons with alcohol problems recruited between 1997 and 2003. We investigated the relation of these markers of HIV(More)
OBJECTIVE To determine factors associated with disclosure of human immunodeficiency virus (HIV)-positive status to sexual partners. METHODS We interviewed 203 consecutive patients presenting for primary care for HIV at 2 urban hospitals. One hundred twenty-nine reported having sexual partners during the previous 6 months. The primary outcome of interest(More)
The purpose of this study was to assess associations between substance use (alcohol to intoxication, heroin, and cocaine) and sexual activity, high risk sexual behaviors, and STD among detoxification inpatients (n = 470). Participants were surveyed on past 30 day substance use, past 6 month sexual behaviors, and STD in the past 6 months and/or over 24(More)
More patients with opioid addiction are receiving opioid agonist therapy (OAT) with methadone and buprenorphine. As a result, physicians will more frequently encounter patients receiving OAT who develop acutely painful conditions, requiring effective treatment strategies. Undertreatment of acute pain is suboptimal medical treatment, and patients receiving(More)
AIM To examine the frequency and severity of low bone mineral density (BMD) among patients enrolled in a methadone maintenance treatment (MMT) program and to ascertain risk factors for low BMD in this population. DESIGN Cross-sectional. MEASUREMENTS Data derived from standardized survey, medical record review, and dual energy X-ray densitometry (DXA).(More)
BACKGROUND The human immunodeficiency virus (HIV)-infected patients on initial presentation to primary medical care may have extensive problems relating to medical, substance abuse, psychiatric, and social issues. We examined a model for the initiation of primary medical care for patients infected with HIV at a public hospital and presented the clinical,(More)
OBJECTIVE To examine delayed presentation for HIV testing and primary care in the second decade of the AIDS epidemic. DESIGN Cohort study in two urban hospitals in the USA between February 1994 and April 1996. METHODS A total of 203 consecutive outpatients on initial HIV primary care presentation were interviewed about sociodemographic characteristics,(More)
AIM We examined the association of substance abuse treatment with uptake, adherence and virological response to highly active antiretroviral therapy (HAART) among HIV-infected people with a history of alcohol problems. DESIGN Prospective cohort study. METHODS A standardized questionnaire was administered to 349 HIV-infected participants with a history(More)
The HIV epidemic has been consistently associated with injection drug use and crack cocaine, but alcohol problems in HIV-infected persons are less well described. Our objectives were 2-fold: (1) to assess the prevalence of alcohol problems in HIV-infected patients initiating medical care; and (2) to determine the positive predictive value of the CAGE(More)