Jeffrey F. Conn

Learn More
Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profound impairment of spatial memory. Effects were associated(More)
The Monadic Phases Coding System (MP) and the Maximally Discriminative Facial Movement Coding System (MAX) are both widely used to define and quantify categories of infant affective behavior. To evaluate the validity of extrapolating research findings from one system to another, we used both systems to code videotapes of 12 four-month-old infants engaged in(More)
The English spoken in the Pacific Northwestern United States (PNWE) has received minimal research attention in variationist sociolinguistics. Labov, Ash and Boberg (2006) and Wolfram and Schilling-Estes (1996) describe this comparatively new region of the United States as likely to show widespread phonological variation due to dialect contact-consistent(More)
Therapeutics, Dissertation title: Mechanisms of cutaneous wound healing are mediated via peripheral neuropeptide activity. Drug discovery efforts to identify novel mGlu5 positive allosteric modulators as potential targets for antipsychotic and cognition-enhancing agents. Drug discovery efforts to identify novel mGlu5 positive allosteric modulators as(More)
Recent studies suggest that increases in intracellular CAMP increase evoked synaptic responses in area CA1 of the hip-pocampus. We recently reported that activation of meta-botropic glutamate receptors (mGluRs) in hippocampal slices potentiates CAMP responses to activation of other receptors that are positively coupled to adenylyl cyclase through Gs. It is(More)
  • 1