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Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7.
Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metabolism enzymes that also play a central role in processing a range of endobiotic compounds. UGTs catalyze theExpand
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The preventive surgical site infection bundle in colorectal surgery: an effective approach to surgical site infection reduction and health care cost savings.
IMPORTANCE Surgical site infections (SSIs) in colorectal surgery are associated with increased morbidity and health care costs. OBJECTIVE To determine the effect of a preventive SSI bundleExpand
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Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting.
BACKGROUND Thoracic endovascular aortic repair (TEVAR) has become the preferred treatment for chronic type B aortic dissection (CTBAD) at our institution. However, it remains incapable of treatingExpand
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The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas.
BACKGROUND Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperativeExpand
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Impact of specific postoperative complications on the outcomes of emergency general surgery patients
BACKGROUND The relative contribution of specific postoperative complications on mortality after emergency operations has not been previously described. Identifying specific contributors toExpand
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Complementary roles of open and hybrid approaches to thoracoabdominal aortic aneurysm repair.
OBJECTIVE Thoracoabdominal aortic aneurysm (TAAA) repair remains a significant challenge with considerable perioperative morbidity and mortality. A hybrid approach utilizing visceral debranching withExpand
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Laparoscopic Versus Open Low Anterior Resection for Rectal Cancer: Results from the National Cancer Data Base
BackgroundWhile the use of laparoscopy has increased among patients undergoing colorectal surgery, there is ongoing debate regarding the oncologic equivalence of laparoscopy compared to open lowExpand
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Trials of nonoperative management exceeding 3 days are associated with increased morbidity in patients undergoing surgery for uncomplicated adhesive small bowel obstruction
BACKGROUND Controversy exists over how long trials of nonoperative management should be pursued in patients with uncomplicated adhesive small bowel obstructions (ASBOs) before deciding to proceedExpand
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Improving Outcomes in Colorectal Surgery by Sequential Implementation of Multiple Standardized Care Programs.
BACKGROUND The purpose of this study was to examine the impact of the sequential implementation of the enhanced recovery program (ERP) and surgical site infection bundle (SSIB) on short-term outcomesExpand
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Evolving practice pattern changes and outcomes in the era of hybrid aortic arch repair.
OBJECTIVE The role of hybrid repair in the management of aortic arch pathology, and long-term outcomes with these techniques, remains uncertain. We report a decade of experience with hybrid archExpand
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