Jeffrey D. Saxe

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Platinum-type drugs have proven to be valuable in the treatment of a variety of solid tumors, beginning with the commercial approval of cisplatin 18 years ago. There are several clinically important toxicities commonly associated with the administration of these drugs. Despite the extensive use of cisplatin and carboplatin, the fundamental chemical(More)
Any approach applied to drug discovery and development by the medical community and pharmaceutical industry has a direct impact on the future availability of improved, novel, and curative therapies for patients with cancer. By definition, drug discovery is a complex learning process whereby research efforts are directed toward uncovering and assimilating(More)
The anti-cancer drug cyclophosphamide produces cytotoxic effects by DNA interstrand crosslink formation. Current knowledge of local physicochemical factors in DNA influencing crosslink formation in DNA has been based on physical models of Watson-Crick DNA. Specific interactions between DNA and cyclophosphamide metabolites determining formation and(More)
The conformational and energetic consequences of cytosine methylation in eukaryotes related to transcription or formation of chromatin structure are not well understood. Structures of methylated and unmethylated DNA sequences from biologically relevant sources were studied by theoretical methods under different ionic conditions and demonstrate that cytosine(More)
Ray tracing is an elegant and powerful technique for creating computer-generated images. The wide variety of geometric primitives and realistic effects, such as reflections, transparency, and shadows, make it one of the most popular rendering methods in use today. We present a brief introduction to ray tracing and discuss some of the computational issues(More)
Molecular dynamics simulations of oligonucleoside methylphosphonates (MP) and naturally occurring oligodeoxynucleotides (ODN) as the third strand to double-stranded (ds) DNA targets predict that the third strand with MP backbone is more favorable to triple helix formation than the native phosphodiester ODN third strand. In contrast to experimental data, the(More)
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