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Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents
The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea, Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing anti-viral,…
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue.
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.
Synthesis of nonracemic 3-deoxyschweinfurthin B.
This represents the first synthesis of the tetracyclic schweinfurthin skeleton, validating the overall synthetic strategy and providing the first schwe infurthin analogue with activity slightly greater than those of the natural products.
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.
The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells
Signaling activity of the dopamine D2R may be involved in the spheroid formation phenotype in the context of the U87MG cell line, but this modulation may not be due to alterations in stemness marker expression, but due to other factors that may contribute to sp heroid formation, such as cell-cell adhesion or EGFR signaling.
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis
GGOHBP significantly reduced whole body tumor burden, significantly slowed the development of tumors, and prolonged overall survival as compared to vehicle treated animals, reiterating a role for protein geranylgeranylation in theDevelopment of prostate cancer metastasis in vivo.
The Mevalonate Pathway and Terpenes: a Diversity of Chemopreventatives
- Jeffrey D Neighbors
- Chemistry, BiologyCurrent Pharmacology Reports
- 27 February 2018
The structural diversity of these compounds is shown and elucidating overlapping mechanistic factors that may be responsible for chemoprevention by the terpenes in general in these effects are elucidated.
3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines
The data suggest that cholesterol homeostasis plays a significant role in the growth inhibitory activity of the schweinfurthins and may elucidate a mechanism that can be targeted in human cancers such as GBM.