Jeffrey Chou

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PURPOSE Combining immunotherapeutic agents with different mechanisms of action may enhance efficacy. We describe the safety and efficacy of talimogene laherparepvec (T-VEC; an oncolytic virus) in combination with ipilimumab (a cytotoxic T-lymphocyte-associated antigen 4 checkpoint inhibitor) in patients with advanced melanoma. METHODS In this open-label,(More)
The SDH activity of the hair cells of sh-1 mice was topographically examined during several days after birth, using the surface preparation method. The activity of this enzyme in sh-1 mice decreased as the animals got older, the outer hair cells being most affected. The level of enzyme activity was different in the three different turns of Corti's organ,(More)
A Phase I/III, multicenter, open-label trial of talimogene laherparepvec (T-VEC) in combination with pembrolizumab for the treatment of unresected, stage IIIb-IV melanoma (MASTERKEY-265) Georgina V Long, Reinhard Dummer, Antoni Ribas, Igor Puzanov, Olivier Michielin, Ari VanderWalde, Robert HI Andtbacka, Jonathan Cebon, Eugenio Fernandez, Josep Malvehy,(More)
MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance(More)
Changes of the cochlear microphonic potentials were studied after replacing the perilymph by various media of different electrolyte composition, containing metabolic inhibitors and with or without energy rich phosphate compound. It was found that the ionic composition of the perilymph was not the only factor affecting the cochlear microphonic potential.(More)
Crista fiberwiegen die Schgden an den Typ-I-Zellen im Vergleich zu den Zellen vom Typ II . I m ganzen betrachtet, weisen jedoch die TypI I Zellen im Zentrum sts Schgdigungen auf als die Typ-I-Zellen in der Peripherie. Auch bei stgrksten Sch/~digungen der Sinneszellen stellten sich bei dieser Versuehsanordnung die Stfitzzellen regelrecht und unauff~llig dar.(More)
enthalten hier nur wenig Stroma, im Gegensatz zu den Randpargen der Geschwuls~, wo ein feinmaschiges Nctzwerk yon Epithelzellen das angrenzende Bindegewebe infiltriert. Bezfiglich der l=iis~ogenese lgBt die papill~re, gelegentlich cystischo Strukbur des Tumors daran denken, da~ wir ein C~rcinom der Anhangsdrfisen des GehSrgangs, also der Ceruminalbzw.(More)
An account is given of a model of the external auditory meatus tumour of the rat which was induced by 4-dimethylaminostilben. Histological, cytogenetical, cytophotometrical and microrespiratory methods have been used to determine the malignity of this kind of tumour. They were well differentiated groups of cells partially cornified squamous epithelial(More)
Introduction T-VEC, an intralesionally-delivered oncolytic immunotherapy, is a herpes simplex virus-1 engineered to selectively replicate in tumors and stimulate an antitumor immune response through expression of GMCSF. T-VEC has the ability to lyse various cancer cell types in vitro[1]. A Phase III study of T-VEC injected into skin, subcutaneous, or lymph(More)
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