• Publications
  • Influence
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.
TLDR
The assignment of LNv neurons as the principal circadian pacemakers controlling daily locomotion in Drosophila is confirmed and PDF is implicate as the Principal circadian transmitter. Expand
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
TLDR
Cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons, and is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Expand
A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila
TLDR
The assignment of LNv neurons as the principal circadian pacemakers controlling daily locomotion in Drosophila is confirmed and PDF is implicate as the Principal circadian transmitter. Expand
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
TLDR
The mutant phenotype results from a premature stop codon that eliminates much of the putative activation domain of this bHLH-PAS transcription factor, thus explaining the dominant features of Jrk and strongly supports common clock components present in the common ancestor of Drosophila and mammals. Expand
CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity
TLDR
It is proposed that CRY is a major Drosophila photoreceptor dedicated to the resetting of circadian rhythms, and physiological and genetic data link a specific photorecept molecule to circadian rhythmicity. Expand
CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless
TLDR
It is proposed that the CYC:CLK heterodimer binds to per and tim E boxes and makes a major contribution to the circadian transcription of Drosophila clock genes. Expand
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
TLDR
Observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of each per gene product causes cycling of its own RNA. Expand
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
Sexual orientation and courtship behavior in Drosophila are regulated by fruitless (fru), the first gene in a branch of the sex-determination hierarchy functioning specifically in the central nervousExpand
Drosophila CRY Is a Deep Brain Circadian Photoreceptor
TLDR
CRY overexpression in brain pacemaker cells increases behavioral photosensitivity, and this restricted CRY expression also rescues all circadian defects of cry(b) behavior. Expand
Signal analysis of behavioral and molecular cycles
TLDR
An adaptation of digital signal analysis is demonstrated that allows similar treatment of both behavioral and molecular data from studies of Drosophila, demonstrating how a unique aggregation of analytical tools may be used to analyze and compare Behavioral and molecular rhythms. Expand
...
1
2
3
4
5
...