Jeffrey Ashley

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In the continuing search for effective cancer treatments, we report the rational engineering of a multifunctional nanoparticle that combines traditional chemotherapy with cell targeting and anti-adhesion functionalities. Very late antigen-4 (VLA-4) mediated adhesion of multiple myeloma (MM) cells to bone marrow stroma confers MM cells with(More)
In this dissertation, we explore the problem of fault detection and fault diagnosis for systems modeled as condition systems. A condition system is a Petri net based framework of components which interact with each other and the external environment through the use of condition signals. First, a system FAULT is defined as an observed behavior which does not(More)
— Condition systems are a form of Petri nets that interact with each other and the external environment through condition signals. Some of these condition signals may be unobservable. In previous work, fault diagnosis was defined in terms of observed behavior versus expected behavior of subsystem models under a single fault assumption, where the expected(More)
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