Jeffrey A. Whitsett

Sort by:

Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.

Timothy J. Gregory, William J. Longmore, +7 authors Thomas M. Hyers
The Journal of clinical investigation
1991

Acute Respiratory Distress Syndrome (ARDS) is characterized by lung injury and damage to the alveolar type II cells. This study sought to determine if endogenous surfactant is altered in ARDS.… (More)

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.

Galen H Fisher, S L Wellen, +6 authors H. E. Varmus
Genes & development
2001

To investigate the role of an activated K-Ras gene in the initiation and maintenance of lung adenocarcinomas, we developed transgenic mice that express murine K-Ras4b(G12D) under the control of… (More)

ABCA3 gene mutations in newborns with fatal surfactant deficiency.

Sergey Shulenin, Lawrence M. Nogee, Tarmo Annilo, Susan E. Wert, Jeffrey A. Whitsett, Michael Dean
The New England journal of medicine
2004

BACKGROUND Pulmonary surfactant forms a lipid-rich monolayer that coats the airways of the lung and is essential for proper inflation and function of the lung. Surfactant is produced by alveolar type… (More)

Hydrophobic surfactant proteins in lung function and disease.

Jeffrey A. Whitsett, Timothy E. Weaver
The New England journal of medicine
2002

Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.

Thomas R. Korfhagen, V Sheftelyevich, +8 authors James H. Fisher
The Journal of biological chemistry
1998

Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted… (More)

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

Gang Chen, Thomas R. Korfhagen, +6 authors Jeffrey A. Whitsett
The Journal of clinical investigation
2009

Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus production are central to the… (More)

Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung.

Urpo Lappalainen, Jeffrey A. Whitsett, Susan E. Wert, Jay W. Tichelaar, Kristina Bry
American journal of respiratory cell and…
2005

The production of the inflammatory cytokine interleukin (IL)-1 is increased in lungs of patients with chronic obstructive pulmonary disease (COPD) or asthma. To characterize the in vivo actions of… (More)

ABCA3 mutations associated with pediatric interstitial lung disease.

Janine E Bullard, Susan E. Wert, Jeffrey A. Whitsett, Michael Dean, Lawrence M. Nogee
American journal of respiratory and critical care…
2005

RATIONALE ABCA3 is a member of the ATP-binding cassette family of proteins that mediate the translocation of a wide variety of substrates, including lipids, across cellular membranes. Mutations in… (More)

GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.

Yoko Shibata, Pierre Yves Berclaz, Zissis C Chroneos, Masaru Yoshida, Jeffrey A. Whitsett, Bruce C. Trapnell
Immunity
2001

GM-CSF gene targeted (GM(-/-)) mice are susceptible to respiratory infections and develop alveolar proteinosis due to defects in innate immune function and surfactant catabolism in alveolar… (More)

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.

Susan E. Wert, Masaru Yoshida, +6 authors Jeffrey A. Whitsett
Proceedings of the National Academy of Sciences…
2000

Targeted ablation of the surfactant protein D (SP-D) gene caused chronic inflammation, emphysema, and fibrosis in the lungs of SP-D (-/-) mice. Although lung morphology was unperturbed during the… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences