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Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques
RationaleSelective phosphodiesterase (PDE) inhibitors improve the formation of hippocampus-dependent memories in several rodent models of cognition. However, studies evaluating the effects of PDEExpand
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Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: antagonist effects of SR 141716A.
This study characterized the antinociceptive, respiratory and heart rate effects of the cannabinoid receptor agonists Delta-9-tetrahydrocannabinol (Delta-9-THC) and WIN 55212 ((R)-(+)-2,Expand
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  • Open Access
Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences.
BACKGROUND Investigations of oral ethanol self-administration in nonhuman primates have revealed important parallels with human alcohol use and abuse, yet many fundamental questions concerning theExpand
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Morphine attenuates ultrasonic vocalization during agonistic encounters in adult male rats
Ultrasonic vocalizations (USV) in rats may communicate “affective” states during pain, sex and aggression. This proposal was evaluated in an experiment with adult male Long-Evans rats duringExpand
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Ethology and Neuropharmacology: Rodent Ultrasounds
One of the most fascinating and instructive illustrations of how neural networks mediate complex communication comes from the neuroethological studies with zebra finches and canaries that sing toExpand
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Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics
A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they becomeExpand
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Diazepam and gepirone selectively attenuate either 20–32 or 32–64 kHz ultrasonic vocalizations during aggressive encounters
Ultrasonic vocalizations (USV) in rats may communicate “affective” states, as they occur only in highly significant behavioral contexts such as during sex, aggression, exposure to painful orExpand
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Interactions between social stress and morphine in the periaqueductal gray: effects on affective vocal and reflexive pain responses in rats
Abstract Rationale: Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexiveExpand
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The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque
RationaleThe current standards of care for Alzheimer’s disease, acetylcholinesterase inhibitors, have limited efficacy due to a host of mechanism-related side effects arising from indiscriminateExpand
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Ultrasounds during morphine withdrawal in rats
Ultrasounds (US) in rats may communicate affective states, as they occur only in highly significant situations such as maternal care, sex and aggression. Withdrawal from morphine is a manipulationExpand
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