Jeffrey A. Silverman

Learn More
Vincristine (VCR) is a mainstay of treatment of hematologic malignancies and solid tumors due to its well-defined mechanism of action, demonstrated anticancer activity and its ability to be combined with other agents. VCR is an M-phase cell cycle-specific anticancer drug with activity that is concentration and exposure duration dependent. The(More)
Intracranial self-stimulation (ICSS) was obtained from 3 areas of anteromedial cortex: the prelimbic area (Brodman's area 32), the anterior cingulate area and the posterior cingulate area. Electrical stimulation in the prelimbic and anterior cingulate areas also produces a behavioral inhibition which is most pronounced at anterior sites (i.e. prelimbic) and(More)
MAIN PURPOSE Voreloxin is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, inducing site-selective DNA damage. Voreloxin is in clinical studies, as a single agent and in combination with cytarabine, for the treatment of acute myeloid leukemia (AML). The preclinical studies reported here were performed to(More)
A curve-shift paradigm was used to assess the effects of lesions of the prefrontal cortex on self-stimulation from electrode sites in the substantia nigra. Combined lesions of the medial and sulcal cortical regions severely attenuated substantia nigra self-stimulation. These results are discussed in the context of the frontal cortex and the substantia nigra(More)
  • 1