Jeffrey A Allen

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OBJECTIVE To describe a patient with reversible posterior leukoencephalopathy syndrome following the administration of bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor. DESIGN Case report/literature review. SETTING University hospital. PATIENT A 52-year-old man receiving chemotherapy for stage IV rectal(More)
When muscular atrophy develops in multiple sclerosis (MS) patients, its etiology may vary from benign to serious. We describe an individual with a 24-year history of MS who developed amyotrophic lateral sclerosis (ALS). The literature is reviewed with particular attention to the clinical and electrophysiologic characteristics of patients with MS and(More)
The acquired immunologic neuropathies are a collection of neuropathic conditions that result from abnormal immune responses that target peripheral nerve myelin, Schwann cells, or axons. Although the clinical features and diagnostic data are sometimes overlapping, the specific disorders are heterogeneous in pathogenesis, treatment, and prognosis.(More)
Neuropathy after vaccination is a rare event. Chronic immune-mediated polyneuropathy developing in the postvaccination period is distinctly unusual and not well described. Almost all such patients have been reported as having typical chronic inflammatory demyelinating polyneuropathy. Distal acquired demyelinating symmetric neuropathy, unlike classic chronic(More)
This article considers several issues of current interest relating to the management of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), including diagnostic pitfalls, differences between CIDP patients with and without concurrent diabetes mellitus and how to best measure treatment response in daily practice. Despite the availability of(More)
OBJECTIVE We aimed to explore the diagnosis and misdiagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) and to identify pitfalls that erroneously lead to a misdiagnosis. METHODS A retrospective study of 59 consecutive patients referred with a diagnosis of CIDP was performed. Patients were classified as having or not having CIDP according(More)
Prolonged intravenous immunoglobulin (IVIG) therapy is used for the chronic autoimmune neuropathies chronic idiopathic demyelinating polyneuropathy and multifocal motor neuropathy, but the doses and treatment intervals are usually chosen empirically due to a paucity of data from dose-response studies. Recent studies of the electrophysiology and immunology(More)
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) can lead to prominent nerve hypertrophy, which can mimic other forms of neuropathy radiologically. Neuro-ophthalmological complications can also occur in CIDP, either at presentation or chronically in the disorder. This can also cause diagnostic difficulties. We report three cases of(More)
Paraneoplastic neuropathy is a potential complication of renal cell carcinoma. The clinical and electrophysiologic features of such patients have not been well characterized. We describe a patient with a demyelinating neuropathy associated with papillary renal cell carcinoma that resolved following nephrectomy. The literature is reviewed with particular(More)
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