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There is currently a lack of evidence-based guidelines to guide the pharmacological treatment of neurobehavioral problems that commonly occur after traumatic brain injury (TBI). It was our objective to review the current literature on the pharmacological treatment of neurobehavioral problems after traumatic brain injury in three key areas: aggression,(More)
Serial assessments are increasingly used in outcomes research to document abnormal changes in cognition. Methods such as the Reliable Change Index (RCI) and Standardized Regression Based (SRB) approaches have been developed to assess reliable test-retest change that attempt to control for practice effects, measurement error and regression to the mean.(More)
Although there have been past literature reviews which have addressed the psychological adjustment, consequences, and impact/reaction to spinal cord injury, as well as reviews of depression after spinal cord injury, there appears to be an absence of reviews which have focused primarily on the relationship between spinal cord injury and anxiety. The purpose(More)
Normal Pressure Hydrocephalus (NPH) is a neurological condition that challenges differential diagnosis, as the symptoms -- cognitive and gait impairment and urinary incontinence -- are similar to those of many aging disorders, including Alzheimer's disease and other forms of dementia. Since NPH is caused by abnormal accumulation of cerebrospinal fluid (CSF)(More)
Ethanol is known to impair cognitive and psychomotor function in high doses. We studied the impairment of cognitive, psychomotor and behavioral responses in controlled environment in a group of healthy young social drinkers at below and above legal limit for presumption of intoxication (100 mg/dl). Attention, concentration, auditory-verbal memory and memory(More)
To date, there has been a relative absence of studies which have examined the utility and effectiveness of sensory stimulation procedures in comatose, spinal-cord-injured patients. This report describes the interdisciplinary utilization (within an acute care setting) of a comprehensive sensory stimulation programme with a 21-year-old, comatose, tetraplegic(More)
We investigated the effect of pretreatment with a prostaglandin synthetase inhibitor, ibuprofen, on the pharmacokinetics and pharmacodynamics of ethanol in six fasting subjects. Ibuprofen caused a 10% decrease in the maximum rate of elimination of ethanol. Visual memory, which is a function primarily mediated by the right cerebral hemisphere, was measured(More)
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