Jeffery B. Blumberg

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PURPOSE Epidemiological studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract. The objectives of this work were to investigate the mechanisms by which these nutrients provide anti-cataract effects. We evaluated their modulation of oxidative damage in human lens epithelial cells (HLEC) and their(More)
The CNS cholinergic agonist spiro-(1-methyl-4-piperidyl)-N-ethyl-succinimide (RS-86) potentiated the ability of typical neuroleptics to inhibit the hyperactivity induced by direct injection of dopamine to the nucleus accumbens of pargyline-pretreated rats. RS-86 did not augment the anti-dopamine actions of clozapine, an atypical neuroleptic. Tricyclic(More)
The cyclic AMP generating system in slices of the rat limbic forebrain was investigated. In consists of: (u) A noradrenergic system which responds to norepinephrine (NE) and isoproterenol. Though the rise of the nucleotide elicited by isoproterenol is more rapid than that caused by NE, the maximal effect is less than half of that induced by NE; (2) an(More)
Subtoxic doses of physostigmine have been found to potentiate the convulsive toxicity and lethality of amitriptyline and imipramine in CD1 and B6A mice. Neostigmine failed to potentiate the toxicity and lethality of imipramine. Physostigmine tended to protect mice against atropine-induced lethality. These data suggest the site of toxicity of this drug-drug(More)
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