Jefferey L. Ebersole

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Volatile sulfur compounds, including hydrogen sulfide (H(2)S), have been implicated in the development of periodontal disease. Glutathione is an important thiol source for H(2)S production in periodontal pockets. Our recent studies have delineated a pathway of glutathione metabolism in Treponema denticola that releases H(2)S. In this pathway,(More)
Hydrogen sulfide (H(2)S) is a major metabolic end product detected in deep periodontal pockets that is produced by resident periodontopathic microbiota associated with the progression of periodontitis. Treponema denticola, a member of the subgingival biofilm at disease sites, produces cystalysin, an enzyme that catabolizes cysteine, releasing H(2)S. The(More)
Role for Recombinant -Glutamyltransferase from Treponema denticola in Glutathione Metabolism Lianrui Chu,* Xiaoping Xu, Zheng Dong,† David Cappelli, and Jefferey L. Ebersole Departments of Orthodontics, Periodontics, and Pathology and Community Dentistry, University of Texas Health Science Center, San Antonio, Texas 78229, and Center for Oral Health(More)
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