Jeff Simpson

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BACKGROUND Peripheral diabetic neuropathy affects between 20% and 45% of patients with diabetes. OBJECTIVE To ascertain the effect of lacosamide on pain associated with peripheral diabetic neuropathy. METHODS One hundred nineteen patients with a 1 to 5-year history of pain attributed to diabetic neuropathy and a score of > or =4 on the Likert pain scale(More)
BACKGROUND Women with chronic inflammatory diseases face uncertainty regarding the safety of biologics during breast feeding. CRADLE was the first industry-sponsored study to evaluate certolizumab pegol (CZP) concentrations in human breast milk and estimate average daily infant dose (ADID) of maternal CZP. METHODS CRADLE (NCT02154425) was a(More)
OBJECTIVES There is a need for effective and safe treatment during pregnancy in women with chronic inflammatory diseases. This study evaluated placental transfer of certolizumab pegol (CZP), an Fc-free anti-tumour necrosis factor drug, from CZP-treated pregnant women to their infants. METHODS CRIB was a pharmacokinetic (PK) study of women ≥30 weeks(More)
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