Jeff Rutgard

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The results of this investigation indicate that 5 X 10(6) and 5 X 10(8) viable bacillus Calmette-Guerin (BCG) organisms (Mycobacterium bovis strain) can be safely administered in the subconjunctival region of the eye of New Zealand albino rabbits without producing toxic effects locally or within the eye. This study provides a format for testing the(More)
Malignant melanoma of the conjunctival region was induced in the golden Syrian hamster. Inoculation of this lesion with Calmette-Guerin bacillus (BCG), 48 hours after injection of 10(3) tumor cells, either slowed, limited, or completely prevented the growth of the tumor in 56% of the treated eyes. In 98% of the control eyes, malignant melanoma grew rapidly(More)
The human lens is composed anteriorly of a single layer of epithelial cells, which undergo mitosis and migrate to the lens equator where they differentiate into lens fiber cells [1]. The elongated lens fiber cells express high levels of soluble crystallin proteins that do not undergo turnover and must remain relatively stable over a lifetime. The(More)
Intravitreal cephalothin was used to treat experimentally induced bacterial endophthalmitis in rabbit eyes. A dose of 2 mg and less was apparently nontoxic to all intraocular structures. Thirty-two hours after injection of a 2 mg dose, the level remaining in the vitreous was above the minimal inhibitory concentration for most susceptible organisms.(More)
We perfused the eyes of albino rabbits with a phosphate buffer to see if the damage to cornea and lens produced by alkali might be reduced. The rabbits were divided into five groups: in the first (control) group undamaged eyes were perfused; in the other four the corneas were burned with sodium hydroxide. The second group was not treated; the remaining(More)
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