Jeff R. Gardner

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A list of 55 chemicals has been developed for which comprehensive in vivo rabbit eye irritation data are available. No new in vivo testing has been carried out to qualify a chemical for inclusion in the list. The 55 chemicals selected are available at high and consistent purity and are expected to be stable on storage. They have been tested undiluted in in(More)
A list of 55 chemicals for which comprehensive rabbit eye irritation data were available was published by ECETOC in 1992. Similar data for a further 77 chemicals are now available. The total of chemicals included in the enlarged data bank is 132, assessed in 149 in vivo studies in rabbits. 28 of the chemicals were tested as solids, 24 as aqueous solutions.(More)
A list of 176 chemicals, all of high or consistent purity and stable on storage, has been developed using available comprehensive in vivo rabbit skin irritation data. No new in vivo testing was conducted to qualify a chemical for inclusion in the list. The chemicals were tested undiluted in in vivo studies, apart from those chemicals where high(More)
We measure experimentally the statistical distribution of time intervals between power-dropout events occurring in a semiconductor laser with time-delayed optical feedback operating in the low-frequency fluctuation regime. Near the laser threshold, the time-interval probability distribution displays a low-probability region, or dead zone, for short times,(More)
We describe a method for stabilizing unstable steady states in nonlinear dynamical systems using a form of extended time-delay autosynchronization. Specifically, stabilization is achieved by applying a feedback signal generated by high-pass-filtering in real time the dynamical state of the system to an accessible system parameter or variables. Our technique(More)
PURPOSE Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior between B cells from CLL and healthy individuals to pinpoint modes of dysregulation. EXPERIMENTAL DESIGN We developed an experimental methodology combining immunophenotyping, multiplexed(More)
This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed that apparent bone volume fraction, trabecular number, and(More)
The collaborative study reported here was performed to evaluate the reliability of the skin corrosivity test in vitro when performed in independent laboratories. Twenty substances were examined in each of three participating laboratories and the results were compared with existing data from standard assays in vivo. The skin corrosivity test is based on the(More)
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