Jeff P. Simmons

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Many material and biological samples in scientific imaging are characterized by nonlocal repeating structures. These are studied using scanning electron microscopy and electron tomography. Sparse sampling of individual pixels in a two-dimensional image acquisition geometry, or sparse sampling of projection images with large tilt increments in a tomography(More)
Ensuring adherence to therapy is a challenge in chronic diseases, particularly in cancers such as chronic myeloid leukemia (CML), where there has been increased availability and use of oral formulations. A conceptual model of adherence was developed based on findings from a comprehensive literature review, to inform strategies for improving adherence to(More)
This paper is concerned with a joint Bayesian formulation for determining the endmembers and abundances of hyperspectral images along with sparse outliers which can lead to estimation errors unless accounted for. We present an inference method that generalizes previous work and provides a MCMC estimate of the posterior distribution. The proposed method is(More)
PURPOSE OF REVIEW Sepsis, defined by the presence of infection and host inflammation, is a lethal clinical syndrome with an increasing mortality rate worldwide. In severe disease, the coagulation system becomes diffusely activated, with consumption of multiple clotting factors resulting in disseminated intravascular coagulation (DIC). When present, DIC(More)
Bright-Field (BF) electron tomography (ET) has been widely used in the life sciences for 3-D imaging of biological specimens. However, while BF-ET is popular in the life sciences, 3-D BF-ET imaging has been avoided in the physical sciences due to measurement anomalies from crystalline samples caused by dynamical diffraction effects such as Bragg scatter. In(More)
High angle annular dark field (HAADF)-scanning transmission electron microscope (STEM) data is increasingly being used in the physical sciences to research materials in 3D because it reduces the effects of Bragg diffraction seen in bright field TEM data. Typically, tomographic reconstructions are performed by directly applying either filtered back(More)
PURPOSE OF REVIEW Optimizing hemostasis with antifibrinolytics is becoming a common surgical practice. Large clinical studies have demonstrated efficacy and safety of tranexamic acid (TXA) in the trauma population to reduce blood loss and transfusions. Its use in patients without pre-existing coagulopathies is debated, as thromboembolic events are a(More)
This letter considers statistical estimation problems where the probability distribution of the observed random variable is invariant with respect to actions of a finite topological group. It is shown that any such distribution must satisfy a restricted finite mixture representation. When specialized to the case of distributions over the sphere that are(More)
We investigate the automated segmentation of microstructures of a nickel-based superalloy using digital microscopy data. We study the combination of a region merging segmentation method called the stabilized inverse diffusion equation (SIDE), and a stochastic segmentation method, the expectation-maximization/maximization of the posterior marginals (EM/MPM)(More)