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The paper describes architectural enhancements to Xilinx FPGAs that provide better support for the creation of dynamically reconfigurable designs. These are augmented by a new design methodology that uses pre-routed IP cores for communication between static and dynamic modules and permits static designs to route through regions otherwise reserved for(More)
OBJECTIVE Repair of demyelinated axons in diseases such as multiple sclerosis requires activation of the myelination program in existing or newly recruited oligodendrocyte precursor cells (OPCs). The control of OPC differentiation and initiation of myelination during repair is poorly understood. In this study, we test the ability of anti-LINGO-1 reagents to(More)
This paper describes CHiMPS, a C-based accelerator compiler for hybrid CPU-FPGA computing platforms. CHiMPSpsilas goal is to facilitate FPGA programming for high-performance computing developers. It inputs generic ANSIC code and automatically generates VHDL blocks for an FPGA. The accelerator architecture is customized with multiple caches that are tuned to(More)
Many-cache is a memory architecture that efficiently supports caching in commercially available FPGAs. It facilitates FPGA programming for high-performance computing (HPC) developers by providing them with memory performance that is greater and power consumption that is less than their current CPU platforms, but without sacrificing their familiar, C-based(More)
This poster describes CHiMPS, a toolflow that aims to provide software developers with a way to program hybrid CPU-FPGA platforms using familiar tools, languages, and techniques. CHiMPS starts with C and produces a specialized spatial dataflow architecture that supports coherent caches and the shared-memory programming model. The toolflow is designed to(More)
Cellular networks may be found in a variety of natural contexts, from soap foams to biological tissues to grain boundaries in a polycrystal, and the characterization of these structures is therefore a subject of interest to a range of disciplines. An approach to describe the topology of a cellular network in two and three dimensions is presented. This(More)
Two different conformational isoforms or amyloid strains of insulin with different cytotoxic capacity have been described previously. Herein these filamentous and fibrillar amyloid states of insulin were investigated using biophysical and spectroscopic techniques in combination with luminescent conjugated oligothiophenes (LCO). This new class of fluorescent(More)