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For decades, hematopoietic stem cells (HSCs) were thought to be a homogeneous population of cells with flexible behavior. Now a new picture has emerged: The HSC compartment consists of several subpopulations of HSCs each with distinct, preprogrammed differentiation and proliferation behaviors. These programs are epigenetically fixed and are stably… (More)
Multiple cell types that share a common origin cooperate to form a supportive niche for stem cells that give rise to blood and to the cells of the immune system.