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Trastuzumab is effective in the treatment of HER2/neu over-expressing breast cancer, but not all patients benefit from it. In vitro data suggest a role for HER3 in the initiation of signaling activity involving the AKT–mTOR pathway leading to trastuzumab insensitivity. We sought to investigate the potential of HER3 alone and in the context of p95HER2 (p95),(More)
  • Jason David Foss, John W Osborn, Van Helden, Pilar Ariza Guzman, Marcus Kuroki, Britta Veitenheimer-Rupp +4 others
  • 2014
i Acknowledgements I would like to thank my advisor, Dr. John Osborn who has been a phenomenal mentor throughout my time in his lab and without whom none of this work would have happened. I would also like to thank the members of my thesis committee Dr. Scott O'Grady, Dr. Stephen Katz and especially Dr. William Engeland who helped us develop our novel(More)
  • Jennifer Allan, Roberto Armenta, Jeff Larson, K S Ashoka, Bhat
  • 2004
The proposed project is a small scale autonomous road vehicle capable of following a line printed on the road. Dubins' cars are kinematic models of wheeled vehicles that move only forward in a plane and possess a lower bounded turning radius. A vehicle will be built that resembles a Dubins' car and it will be controlled using a PID controller. If time(More)
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