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The availability of drugs targeting the EGFR/HER/erbB signaling pathway has created a need for diagnostics that accurately predict treatment responses. We have developed and characterized a novel assay to provide sensitive and quantitative measures of HER proteins and homodimers in formalin-fixed, paraffin-embedded (FFPE) cell lines and breast tumor(More)
Trastuzumab is effective in the treatment of HER2/neu over-expressing breast cancer, but not all patients benefit from it. In vitro data suggest a role for HER3 in the initiation of signaling activity involving the AKT–mTOR pathway leading to trastuzumab insensitivity. We sought to investigate the potential of HER3 alone and in the context of p95HER2 (p95),(More)
The proposed project is a small scale autonomous road vehicle capable of following a line printed on the road. Dubins' cars are kinematic models of wheeled vehicles that move only forward in a plane and possess a lower bounded turning radius. A vehicle will be built that resembles a Dubins' car and it will be controlled using a PID controller. If time(More)
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