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A Working Group on Research in Hypertension in Pregnancy was recently convened by the National Heart, Lung, and Blood Institute to determine the state of knowledge in this area and suggest appropriate directions for research. Hypertensive disorders in pregnancy, especially preeclampsia, are a leading cause of maternal death worldwide and even in developed(More)
BACKGROUND Blood pressure (BP) level is a major determinant of cardiovascular morbidity and mortality in individuals with diabetes mellitus. Several guidelines recommend lower BP goals and specific drug classes for these patients. The overviews reported herein were performed to formally compare the effects on cardiovascular events and death of different(More)
BACKGROUND Type 2M von Willebrand disease (VWD) results from mutations in the A1 domain of von Willebrand factor (VWF) that reduce its platelet-binding function. However, currently employed VWF functional static assays may not distinguish between clinical phenotype. METHODS Fifteen individuals from five kindreds with VWF-A1 domain mutations I1416T or(More)
X-linked and autosomally inherited bleeding disorders confer a risk of foetal intracranial haemorrhage during delivery. Conventional prenatal diagnosis involving chorionic villus sampling or early amniocentesis is primarily aimed at offering the choice of pregnancy termination. Currently, non-invasive procedures, involving analysis of free foetal DNA in the(More)
Three hundred thirty-nine migrant worker women and children were screened by single stool examination for intestinal parasites. Infection occurred in 34.2%. Giardia lamblia and Trichuris trichiura were the most common pathogens; Entamoeba coli and Endolimax nana were the most common commensals. Infants under 1 year of age were free of infection. Children(More)
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